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Richard T. Silver MD Myeloproliferative Neoplasms Center

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Anagrelide (Agrylin®)

Anagrelide, also known by the brand name Agyrlin®, is a prescription, oral medication used to treat Essential Thrombocythemia (ET). Patients with ET have too many platelets in the blood, and anagrelide works to decrease the production of platelets in the body. By reducing blood platelet numbers, anagrelide, it thought to reduce the excess risk of blood clots in patients with ET. Anagrelide works by inhibiting the maturation of the platelet precursor cells, megakaryocytes and in this way reducing the production of platelets.

Side Effects

Common side effects:
Many of these side effects improve over time but it is important to tell your doctor about any side effects you may be experiencing.

  • Diarrhea or loose bowel movements
  • Headaches
  • Palpitations

Potential serious side effects:

  • Abnormal Heart Rhythm
  • Heart failure or reduced heart function

Drug Interactions:
This medication can interact with certain other medications you may be taking. Be sure to tell your doctor all medications you’re taking. Also, be sure to tell you doctor about any medical problems as this may be important in deciding whether anagrelide is appropriate for you. 

For additional information, visit: https://medlineplus.gov/druginfo/meds/a601020.html

Richard T. Silver MD Myeloproliferative Neoplasms Center 525 East 70th St., Starr Pavillion, 3rd Floor New York, NY 10021 SilverMPNCenter@med.cornell.edu